ZFIN Image: Zhong et al., 2011, Fig. S3

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Figure Caption

Fig. S3 DN-CLIM but not N-SSDP1 over-expression induces patterning defects specifically in the hindbrain. A: Dorsal views of the hindbrain (rostral is up) of 24 hpf embryos immuno-labeled with the 3A10 antibody are shown. Development of Mauthner neurons (arrows) and crossing of their axons at the brain midline (arrowhead) is not affected by N-SSDP1 over-expression. In contrast, DN-CLIM over-expression leads to complete or partial loss of Mauthner neurons. Note that in those cases in which only one Mauthner neuron is present its axonal trajectory is not altered (ov = otic vesicle). B: Lateral views of the spinal cord show that 3A10 immuno-labeled CoPA neurons (arrowheads) and their commissural axons (arrows) are not affected by N-SSDP1 or DN-CLIM over-expression. Scale bars = 50 μm.

Acknowledgments

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Reprinted from Developmental Biology, 349(2), Zhong, Z., Ma, H., Taniguchi-Ishigaki, N., Nagarajan, L., Becker, C.G., Bach, I., and Becker, T., SSDP cofactors regulate neural patterning and differentiation of specific axonal projections, 213-224, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.