ZFIN Image: Zhong et al., 2011, Fig. 4

Image

Figure Caption

Fig. 4 N-SSDP impairs eye and MHB development. A, B: Lateral views of the heads of living (A) or fixed, anti-tubulin immuno-labeled (B) 24 hpf embryos are shown. N-SSDP1 mRNA injection leads to reduced eye and MHB size compared to control embryos. DN-CLIM mRNA completely inhibits eye development and more strongly affects the MHB. C: Eye size is significantly reduced after N-SSDP1 mRNA over-expression compared to NLS-myc control mRNA over-expression. D: Dorsal (left columns) and lateral views (right columns) of whole-mounted 24 hpf embryos reveal loss of Pax2a and reduction of Wnt-1 mRNA expression in the MHB after N-SSDP1 mRNA over-expression. Scale bars = 200 μm (A, B and D).

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Reprinted from Developmental Biology, 349(2), Zhong, Z., Ma, H., Taniguchi-Ishigaki, N., Nagarajan, L., Becker, C.G., Bach, I., and Becker, T., SSDP cofactors regulate neural patterning and differentiation of specific axonal projections, 213-224, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.