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Fig. S3 The off-target effects of irx1a and irx2a morpholinos are mediated through p53-induced apoptosis. Injection of p53 knockdown morpholino rescued the off-target effects, including reduced body size and curvature of the tail, induced by irx1a morpholino MO2 (D, E) and irx2a morpholino MO2 (B, C). Embryos with co-injection of p53 MO and irx2a MO2 (C, F) or irx1a MO2 (E) still displayed a small eye phenotype (F). Thus, the eye defect was a specific loss of function phenotype of irx1a or irx2a knockdown embryos.
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