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Fig. 3 Histopathology of nlz morphant fish. Coronal (A–C) and sagittal (D–H) planes through the zebrafish eye. Normal retinal lamination and a fused ventral fissure can be seen in control MO injected fish at 5 dpf (A and D) and at 6 dpf (G) (Top, dorsal; Bottom, ventral). Fissure closure defects can be seen in nlz1 morphant fish at 5 dpf (B and E) and 6 dpf (H) and nlz2 morphant fish at 5 dpf (C and F). The coloboma in morphant fish is accompanied by discontinuous RPE (black arrowhead), retinal dysplasia/rosettes (arrows), and abnormal vasculature (open arrowhead). H&E staining.
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