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Fig. 6 Overexpression of bmp2b restores DV patterning in embryos depleted of maternal Ship2a. (A-F) eve1 expression in WT or ship2a-morphant 50% epiboly embryos and similar embryos that had been injected with bmp2b mRNA. (A,C,E) eve1 expression is restricted to the ventral side of WT embryos and downregulated in ship2a MO1- or MO2-injected embryos. (B) Overexpression of bmp2b in WT embryos results in the dorsalward expansion and circumferential expression of eve1, indicating that ectopic bmp2b expression promotes ventralization. (D,F) Co-injection of bmp2b mRNA with either ship2a MO1 or MO2 restores the WT expression pattern of eve1.