ZFIN Image: Vermot et al., 2009, Fig. S1

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Figure Caption

Fig. S1 Oscillatory flow is observed in the AV canal before valves become functional. (A-D) Confocal scans of hearts (ventral view, anterior to the top) at four developmental stages showing the morphology of the developing heart between 36 and 120 hpf. The endocardial tissue in the AV canal at 48 hpf in shown by the arrow in (C). Valve leaflets appear at 84 hpf and are mature by 120 hpf. The black box underlines the location of blood flow analysis for each stage (A-D). Scale bar indicates 50 μm. (E-H) Transvalvular flow direction over time shows that mature valve leaflets are necessary to prevent retrograde flow in the heart. Anterograde flow from the atrium to ventricle is shown in black, retrograde flow from the ventricle to the atrium in red, and no flow between the chambers is shown in white.

Acknowledgments

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