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Fig. S4 NPTX2 protein alignment and expression profile of nptx2a. (A) Alignment of mouse (m) NPTX2 (accession number: NP_058069) and zebrafish (z) NPTX2a (FJ232033) and NPTX2b (FJ232032) protein sequences. The N-terminal is predicted to form coiled-coil domains (underlined) while the C-terminal encodes a pentraxin domain (red font). A putative signal peptide sequence region is indicated in bold. (B, C) Dorsal (B) and lateral (C) views of 2 dpf larvae demonstrate widespread nptx2a expression, most notably in the olfactory bulb (OB), midbrain tegmentum (T), tectum opticum (TeO), pituitary gland (Pi) and cranial ganglia (CG).