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Fig. S7
Lsd1 and Ctbp1 Are Upregulated in apc Mutant Zebrafish Embryos, Related to Figure 7
(A) Immunoblot showing that apcmcr zebrafish embryos express higher levels of Lsd1 and Ctbp protein compared to apcwt siblings (at 72hpf). Vinculin is used as a loading control.
(B and C) apcmcr zebrafish were injected with lsd1/corest/control morpholino at the one cell stage. Total protein was harvested at 72hpf. Immunoblotting was performed with the indicated antibodies.
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Reprinted from Cell, 142(6), Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A., DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC, 930-942, Copyright (2010) with permission from Elsevier. Full text @ Cell