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Fig. 10 Excitation-Contraction Coupling abnormalities in myotubularin morphants.
Excitation-contraction (E–C) coupling. Control morphant myofibers could respond to 15 ms depolarizing current injections to 0 mV from 0 to 30 Hz (average max frequency = 27.0+/-0.9 Hz, N = 5). In contrast, myotubularin morphant muscle progressively failed to contract to stimuli above 10 Hz (average maximum frequency = 11.5+/-1.5 Hz, N = 5, p<0.0001).
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