ZFIN Image: McGrail et al., 2010, Fig. 5

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Figure Caption

Fig. 5 Increased expression of prom1a and prom1b in epitheloid-like cells in tp53^M214K/tp53^M214K induced neoplasm. A, B, E, F: Gross morphology and histopathology of abdominal (A, B) and ocular (E, F) neoplasms in 12-month-old adult homozygous tp53^M214K/tp53M214K zebrafish. B: Histopathological features of the abdominal neoplasm show regions with predominantly spindle cells (solid line box) or predominantly epitheloid cells (dashed line box), consistent with a diagnosis of zMPNST (Berghmans et al., [2005]). F: Histopathological features of ocular tumor show predominantly spindle cells, consistent with a diagnosis of zMPNST (Berghmans, et al., 2005). C, D: Expression of prom1a (C) and prom1b (D) is detected within epitheloid-like cells in the abdominal neoplasm (solid line box), but is absent from the region containing predominantly spindle cells (dashed line box). G, H: Absence of expression of prom1a (G) and prom1b (H) in spindle cells of the ocular neoplasm. Scale bars in A, E = 0.5 cm; in H = 50 μm.

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Expression / Labeling details

Acknowledgments

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