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Fig. 12 Absence of Atoh8 affects the myogenic differentiation of skeletal muscle.
(A–B) transverse section of somites at 3dpf and (C–D) transferse section of somites at 7dpf. (A,C) somites of Atoh8-treated embryos; (B,D) the related controls. Note that the transverse myoseptum of MO-treated embryos is ill-defined and incomplete and that the somites form a U-shape or even appear cuboidal. Somites in controls, on the other hand, are chevron shaped with a distinct somite boundary. In addition, differentiated muscle fibers in myotomes show a less compact and orderly looking arrangement in the morphant.
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