ZFIN Image: Piloto et al., 2010, Fig. 8

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Figure Caption

Fig. 8 rab11fip2 genetically interacts with ncad to regulate NC migration. (A-F) Live images of tg:sox10(7.2):gfp labeling migratory NC cells in ncad^+/- embryos (A-C) and single Ncad morphants (D-F). In contrast to controls (A,D), Gfp-positive NC cells remain in the dorsal neural tube of ncad^+/- mutants [B,C; arrows; examples (Ex) 1 and 2] and Ncad morphants (E,F; arrows) injected with subthreshold levels of Rab11fip2 mRNA. (G-I) Similarly, ectopic mitfa-positive cells cluster in the dorsal midline (arrows) of ncad^+/- mutants (H) and Ncad morphants (I) overexpressing Rab11fip2, but not in controls (G). (J) Quantitation of genetic interaction studies; numbers of embryos with or without ectopic sox10⁺ NC clusters in the dorsal midline (blue and red bars, respectively). ot, otic vesicle.

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