ZFIN Image: Nguyen et al., 2010, Fig. 6

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Figure Caption

Fig. 6 Craniofacial phenotypes of leo1^LA1186. (A, B, C, D) Alcian blue staining of wild-type (A, C) and leo1^LA1186 embryos (B, D) at 3 days post fertilization. Leo1^LA1186 exhibit severe craniofacial defects including absence of the ethmoid plate from the anterior neurocranium and complete loss of pharyngeal arches. (A, B) Lateral view. (C, D) Ventral view. ANC, anterior neurocranium; t, trabecular cranii; m, mandibular arch; h, hyoid arch; P3–7, pharyngeal arches 3–7. (E, F, G, H) Tbx1 and endothelin-1 (edn-1) expression patterns in the pharyngeal arch epithelium and mesenchymal core are indistinguishable between wild-type embryos (E, G) and leo1^LA1186 mutants (F, H) at 27 hpf.

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Acknowledgments

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Reprinted from Developmental Biology, 341(1), Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N., The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish, 167-175, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.