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Fig. 7 RPTPα and PTPε knockdown phenotypes were enhanced by wnt11 knockdown and induced cyclopia. (A) Zebrafish embryos were injected with low amounts of morpholino targeting RPTPα (0.15 ng/embryo), PTPε (1 ng each/embryo) and Wnt11 (2 ng/embryo) and grown to 3 dpf. Embryos were scored based on morphology “cyclopia” when eyes were fused, as “phenotype” when shorter, showing abnormal morphology and/or edemas, or as “normal”. The percentages of embryos with phenotypes were plotted. Representative embryos from each (co-)injection are depicted in panels B–E.
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Reprinted from Developmental Biology, 340(2), van Eekelen, M., Runtuwene, V., Overvoorde, J., and den Hertog, J., RPTPalpha and PTPepsilon Signaling via Fyn/Yes and RhoA is Essential for Zebrafish Convergence and Extension Cell Movements during Gastrulation, 626-639, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.