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Fig. S4 Impaired convergence in the anterior neural plate. Shown are embryos labeled with riboprobes against pax2.1 and krox20. At 2 somite stage, the neural plates of wild type and morphant embryos are comparable in width. However, by 5 somite stage, the neural keel has narrowed considerably in wild type embryos, but remains much wider in pcdh19 morphants. This indicates that morphogenesis occurring prior to the 2 somite stage is largely unperturbed, and that convergence movements occurring between the 2 and 5 somite stages are impaired by the loss of Pcdh19 function.
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Reprinted from Developmental Biology, 334(1), Emond, M.R., Biswas, S., and Jontes, J.D., Protocadherin-19 is essential for early steps in brain morphogenesis, 72-83, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.