ZFIN Image: Calarco et al., 2009, Fig. S13

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Figure Caption

Fig. S13 Phenotype of nSR100 MOspl morphant embryos. A-B. Lateral views of control p53MO-injected (A) and nSR100 MOspl-injected (B) embryos at 30hpf. nSR100 morphant embryos exhibit only a slight delay in embryonic development, as exhibited by morphogenesis of the midbrain-hindbrain boundary (asterisks). C-D. Lateral (C, D) and ventral (C′, D′) views of control p53MO-injected (C, C′) and nSR100 MOspl-injected (D, D′) embryos at 48hpf. Note the expanded ventricle (arrowhead) and convoluted body axis of nSR100 morphant embryos. However, general embryonic patterning and morphogenesis of nSR100 morphants, including heart formation (arrows), appears relatively normal.

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Reprinted from Cell, 138(5), Calarco, J.A., Superina, S., O'Hanlon, D., Gabut, M., Raj, B., Pan, Q., Skalska, U., Clarke, L., Gelinas, D., van der Kooy, D., Zhen, M., Ciruna, B., and Blencowe, B.J., Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein, 898-910, Copyright (2009) with permission from Elsevier. Full text @ Cell