ZFIN Image: Olesnicky Killian et al., 2009, Fig. S6

Image

Figure Caption

Fig. S6 Overexpression of sdf1b and cxcr4a results in CNCC defects. Lateral views, anterior to the left of 28 hpf embryos (A,B). (A) WT tg{sox10::eGFP} embryos show normal pharyngeal arch patterning, while embryos injected with cxcr4a mRNA (B) show pharyngeal arch defects, with much of arch 1 missing and ectopic CNCCs ventro-lateral to the arch region along the yolk (arrows). Embryos injected with sdf1b mRNA (C) show similar arch defects to cxcr4a mRNA overexpression with fusion of arch 1 and 2. Lower (10x) magnification of embryo injected with sdf1b mRNA showing ectopic CNCCs along the yolk ventral to the eye and pharyngeal arches (D, arrows). Inset shows 20x magnification of ectopic CNCCs along yolk. eye is outlined with white line in panels A–C.

Acknowledgments

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Reprinted from Developmental Biology, 333(1), Olesnicky Killian, E.C., Birkholz, D.A., and Artinger, K.B., A role for chemokine signaling in neural crest cell migration and craniofacial development, 161-172, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.