ZFIN Image: Sun et al., 2009, Fig. 6

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Figure Caption

Fig. 6 Phenylhydrazine hydrochloride treatment of wild-type zebrafish recapitulates the cardiac remodeling process of tr265/tr265.

(A–A′) PHZ treatment results in anemia in zebrafish, as evidenced by (A′) the paleness in the gill region, compared to (A) the control; bar = 1 mm. (B–B′) (B′) Anemia-induced cardiomegaly seen after three weeks of treatment versus (B) the control; bar = 1 mm. (C) Ventricle area to body length index of week-6, week-13, and year-1.5 control and PHZ-treated fish. (D) Body length (in mm) of the control vs. PHZ-treated fish. (E) MEF2⁺ cell density (cells/mm²) of year-1.5 control and treated fish. (F) Percent of proliferating MEF2⁺ cells in year-1.5 control and treated fish. (G) Percent relative hemoglobin concentration in the year-1.5 control and treated fish. (C–G) mean±SEM; * = P<0.05; n = number of fish examined.

Acknowledgments

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