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Fig. 10 Expression of Fgf-target genes is altered in lmx1b morphants. Whole mount in situ hybridization in 24 hpf embryos for erm, pea3, and spry2 (A–C, F–H) and fluorescence in Tg(dusp6:dEGFP) (D, E, I, J). For each Fgf-target gene, note the expansion in periocular and ocular regions and reduction in the MHB. For dusp6:GFP, sections confirmed up-regulation of GFP in the dorsal neural retina, lens, and optic stalk regions (E, J). Sections were counter-stained with propidium iodide to highlight nuclei (red).
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Reprinted from Developmental Biology, 332(2), McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A., Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish, 287-298, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.