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Fig. S3
SmoC151Y fails to localize to the cilium.
Expression of the ciliary marker acetylated Tubulin (green) and Myc-tagged (red) wild-type Smo (A), Myc-tagged SmoC151Y (B) or CLDSmo (C-D) in NIH 3T3 cells. Nuclei were visualized with DAPI (blue). Low levels of wild-type Smo expression did not cause its ciliary localization in the absence of Shh or purmorphamine; SmoC151Y or CLDSmo was not detected on the cilia even in the presence of Shh or purmorphamine (see also Suppl. Fig. 5).
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