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Figure Caption
Fig. S11
NO modifies the effects of notch signaling on HSC formation.
Zebrafish embryos were assessed by in situ hybridization for runx1/cmyb at 36 hpf.
(A-D) wild-type and mib-/- mutant embryos were exposed to DMSO and SNAP (10 μM) from 10 somites to 36 hpf. NO rescued the HSC defect in mib-/- embryos.
(E-H) Inhibition of NO by L-NAME (10 μM) diminished the enhancing effect of constitutive notch activation in NICD transgenic zebrafish embryos.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell