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Fig. S6
Time course analysis reveals time-specific effect of NO modulation on HSCs.
(A-O) Embryos were exposed to L-NAME and SNAP from 10 somites until fixation (22 - 72 hpf).
(A-F) SNAP exposure does not increase the expression of HSC markers at early stages.
(G-O) nos inhibition by L-NAME does not cause a delay in HSC development that can be compensated for at later developmental stages.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell