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Fig. S4
Modulation of NO has dose-dependent effects on HSC formation.
(A-L) Embryos (n>25 per treatment) were exposed to increasing doses of L-NAME (B-F) or SNAP (H-L) from 10 somites to 36 hpf. With increasing L-NAME dose, HSC formation was progressively diminished. Similarly, SNAP lead to a dose-dependent increase of runx1/cmyb expression. Doses >20 μM for each drug led to gross morphological abnormalities.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell