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Fig. S2
APC-KRAS and APC-RAF1 Share Morphologic Abnormalities that Are Distinct from APC-MEK1 Embryos
(A) apcmcr zebrafish embryos were injected with constitutively active KRAS, RAF1 or MEK1. Protein lysate from 72 hpf embryos was harvested and subjected to western blot analysis for phosphor-Erk (top) and vinculin (bottom). (B) Embryos injected as above were fixed and photographed at 72 hpf. All images represent at least three independent experiments.
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Reprinted from Cell, 137(4), Phelps, R.A., Chidester, S., Dehghanizadeh, S., Phelps, J., Sandoval, I.T., Rai, K., Broadbent, T., Sarkar, S., Burt, R.W., and Jones, D.A., A two-step model for colon adenoma initiation and progression caused by APC loss, 623-634, Copyright (2009) with permission from Elsevier. Full text @ Cell