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Fig. 1 apcmcr/mcr fish fail to express some differentiation markers in endoderm-derived tissues. Dorsal view of 72 hpf in wild-type (A, C, E, G) and apcmcr/mcr (B, D, F, H) siblings after WISH for intestinal-fatty acid binding protein (i-fabp) (A, B), trypsin (C, D), liver fatty acid binding protein (l-fabp) (E, F), and insulin (G, H). i-fabp and l-fabp expression is absent in apcmcr mutants, whereas trypsin expression is strongly reduced in these embryos: insulin expression is not affected. Arrowhead indicates ectopic expression of insulin marker in apc mutants (H).
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