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Fig. S3 Effect of PrP-1 Knockdown on Apoptosis and Mitosis Rates
(A–D) DAPI stainings on 6-hpf embryos (B and D) do not reveal morphological signs of increased apoptosis (such as chromatin condensation and nuclear fragmentation) in detached knockdown cells (C) compared to control embryonic cells (A).
(E) PrP-1 morphant embryos show a clear reduction in the number of mitotic cells at 6 hpf (p = 4.3 x 10-7; triple asterisks [***] indicate statistical significance at p < 0.001); however, neither cell size nor overall cell density seems significantly affected (see main text).
Scale bars in (A–D) indicate 10 μm.
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