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Fig. 8 A model: unrestricted cross-midline divisions disrupt rhombomere boundaries in an EphA4; EfnB2a MO embryo. In a WT hindbrain, daughter cells created by cross-midline divisions in r3, r4 and r5 are restricted by the presence of cell surface EphA4 and EfnB2a to intercalate well inside their respective rhombomeres of origin. Neuroepithelial cells in r3–5 in embryos lacking EphA4 and EfnB2a divide without such restrictions, leading to mis-sorting of daughters from r3 and r5 mothers into r4 and vice versa.
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Reprinted from Developmental Biology, 327(2), Kemp, H.A., Cooke, J.E., and Moens, C.B., EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel, 313-326, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.