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Fig. 6 Cell sorting is prevented by inhibiting cell division in the neural keel/rod. Dorsal views of 18 hpf mosaic embryos with anterior to the left. (A) EphA4 MO donor cells (red) sort out of r3 and r5 of a WT pGFP5.3 host (green) treated with solvent alone (4% DMSO; N = 10). (B) Treatment of mosaic embryos from 90% epiboly onwards with cell cycle inhibiting drugs inhibits cross-midline divisions and also prevents sorting-out of EphA4MO cells from r3 and r5 (N = 7/11). Scale bar: 50 μm.
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Reprinted from Developmental Biology, 327(2), Kemp, H.A., Cooke, J.E., and Moens, C.B., EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel, 313-326, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.