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Fig. S2 Mutated Dnd proteins translated of RNAs containing the Vasa 3′UTR fail to support PGC survival in dnd MO injected embryos. Embryos were injected simultaneously with dnd MO and mRNA of Dnd mutants, fixed at 24hpf and subjected to in situ hybridization with vasa anti sense probe. Similar to the nanos1 3′UTR results, RNAs encoding Dnd mutated in certain critical amino acids failed to reverse the effect of the antisense oligonucleotides.
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Reprinted from Mechanisms of Development, 126(3-4), Slanchev, K., Stebler, J., Goudarzi, M., Cojocaru, V., Weidinger, G., and Raz, E., Control of Dead end localization and activity – Implications for the function of the protein in antagonizing miRNA function, 270-277, Copyright (2009) with permission from Elsevier. Full text @ Mech. Dev.