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Fig. 3 NeuroD increases the expression of cyclin inhibitors and inhibits the expression of cyclins. Panels A, C, E, G and I illustrate retinas from wt embryos heat-shocked at 24hpf, sacrificed at 48hpf and processed for in situ hybridization with probes for p27, p57, Cyclin D1, Cyclin B and Cyclin E, respectively. Panels B, D, F, H and J are transgenic embryos treated similarly. Scale bars equal 50 μm.
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Reprinted from Mechanisms of Development, 126(3-4), Ochocinska, M.J., and Hitchcock, P.F., NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish, 128-141, Copyright (2009) with permission from Elsevier. Full text @ Mech. Dev.