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Figure Caption
Fig. 11 Alteration of T-tubule/SR component localization in myotubular myopathy.
Muscle from 3 myotubular myopathy patients and an age matched control were immunostained with DHPRa1 to mark T-tubules (A) and RYR1 to mark the adjacent sarcoplasmic reticulum (B). Abnormal distribution of DHPRa1 and RYR1 was observed in numerous fibers in all 3 myotubularin patients but in none of the control fibers (arrows). Scale bar = 20 mm.
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