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Figure Caption
Fig. 9 T-tubule structural abnormalities in myotubularin morphant muscle.
T-tubule (vertical arrows) and sarcoplasmic reticulum (angled arrows) abnormalities as demonstrated by electron microscopy. Control morphant (panel 1; CTL): normal T-tubule triad with accompanying thin, well-organized SR network (arrow). Myotubularin morphants (panels 2–4): Panel 2 shows mildly dilated triads and SR networks. Panel 3 shows severely dilated and dysmorphic triads and widely looped SR. Panel 4 illustrates severe disorganization, with unrecognizable T-tubule triads and aberrant adjacent SR networks. Scale bar = 500 nm.
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