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Fig. 4 Ectopic BMP signaling reverses LR asymmetry in heart precursors. Dorsal view of whole-mounted embryos, anterior to the left, except F which is an anterior view with dorsal to the top. (A, B) In situ hybridization showing assymetric expression of fli-1 in the putative endocardium (arrow) in uninjected control and reversed in a BMP4-injected embryo. (C, D) BMP4 expression itself is expressed with reversed asymmetry relative to the midline (white line) following BMP2 injection. (E, F) DM-GRASP expression in an uninjected control (E) and a BMP4-injected embryo (F). Scale bar, 100 μm.
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Reprinted from Developmental Biology, 210(2), Schilling, T.F., Concordet, J.-P., and Ingham, P.W., Regulation of left-right asymmetries in the zebrafish by Shh and BMP4, 277-287, Copyright (1999) with permission from Elsevier. Full text @ Dev. Biol.