ZFIN Image: Chakraborty et al., 2009, Fig. 5

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Figure Caption

Fig. 5 Inactivation of p53 rescues the morphological defects and apoptosis in L11-deficient embryos.

(A, B) Morphology of L11-deficient embryos coinjected with either p53 MO or p53 misMO compared to the control embryos at 24 hpf. The overall body length, midbrain-hindbrain boundary (arrow in A), and enlarged forebrain (asterisk in B) are rescued in p53 MO, but not in p53 misMO-injected L11-deficient embryos. (C, D) TUNEL staining of p53 MO injected L11-deficient embryos. The numbers of apoptotic cells (TUNEL-positive cells in D) are reduced, almost similar to those in wild-type embryos, in p53 MO-coinjected embryos compared to rpl11 MO alone–injected embryos. All images are in lateral views with the anterior to the top in A and D and to the left in B. Scale bars: A, 500 μm; B and D, 200 μm.

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Acknowledgments

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