ZFIN Image: Esterberg et al., 2009, Fig. 9

Image

Figure Caption

Fig. 9 Manipulation of PPR-inducing signals can rescue the otic phenotype of Dlx3b/4b morphants. (B) Dlx3b/4b morphants display a small, circular otic vesicle that lacks otoliths. (C,D) The otic phenotype of Cv2 morphants resembles that of Dlx3b/4b morphants (B), and is not significantly affected by the additional loss of Dlx3b/4b (D). (E,F) Ectopic expression of cv2 mRNA can rescue the Dlx3b/4b otic phenotype (F). (G–L) While heat shock of tBR embryos (G), knockdown of Bmp4 (I), or ectopic fgfr1 expression (K) does not affect ear morphology, each is able to partially rescue the otic phenotype of Dlx3b/4b morphants (H,J,L). All embryos are 30 hpf; lateral views, with anterior to the left.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 325(1), Esterberg, R., and Fritz, A., dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity, 189-199, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.