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Fig. S4 The Pard6 protein family. (A) Clustal W (1.83) Multiple Sequence Alignment of the four zebrafish (ZF) Pard6 proteins with the three mouse (MM) Pard6 proteins and the C.elegans (CE) PAR-6 protein. The red box outlines the conserved PB1 domain. The green box outlines the conserved CRIB domain. The yellow boxes outline the conserved PDZ domain. (B) Cladogram of the four zebrafish (ZF) Pard6 proteins, three mouse (MM) Pard6 proteins, and the C.elegans (CE) PAR-6 proteins. (C) in situ hybridization analysis shows pard6β expression at 24 hpf in the otic placodes (arrow).
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Reprinted from Developmental Biology, 324(1), Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y., Regulation of neurocoel morphogenesis by Pard6gammab, 41-54, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.