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Fig. 4 BMP activity establishes proliferation in axial mesoderm. (A-D″) Longitudinal sections through the tailbud of 14-somite embryos exposed to PSMAD1/5/8 (red) and BrdU (green) antibodies reveal that axial cells undergoing proliferation are responding to BMP activity. Cell proliferation is increased in axial tissue of Fstl1/2 morphants (B-B″), and reduced in tBR embryos heat-shocked at 80% epiboly (C-C″) and Bmp4 morphants (D-D″). Arrowheads indicate the CNH. Anterior is towards the left in all views. Brackets and arrows indicate the expanse and absence of proliferation in chordamesoderm, respectively.