ZFIN Image: Chung et al., 2008, Fig. S2

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Figure Caption

Fig. S2 Bmp Signaling Regulates pdx1 Expression
(A–D) Dorsal views of pdx1 expression, comparing wild-type (A and C), Tg(hsp70l:dnBmpr-GFP)^w30 (B) and Tg(hsp70l:bmp2b)^f13 (D) hemizygous embryos at 18 hpf. pdx1 is expressed at high levels in the most medial cells (asterisks) and at low levels in the lateral cells (arrows) in wild-type (A and C). (B) In Tg(hsp70l:dnBmpr-GFP)^w30 hemizygous embryos heat-shocked at the 6-somite stage, pdx1 expression was expanded laterally (the percentage of embryos showing a substantial lateral expansion of pdx1 expression was 60%, n = 18/31). (D) In Tg(hsp70l:bmp2b)^f13 hemizygous embryos heatshocked at the 8-somite stage, high levels of pdx1 expression (asterisks) were maintained, while low levels (arrows in A, B and C) were severely reduced (the percentage of bmp2b).

Acknowledgments

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Reprinted from Developmental Cell, 15(5), Chung, W.S., Shin, C.H., and Stainier, D.Y., Bmp2 signaling regulates the hepatic versus pancreatic fate decision, 738-748, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell