Fig. 5 Developmental effects of C1q-like over-expression and UV exposure on zebrafish embryo development. (A) C1q-like expression changes detected by Q-RT-PCR at different times after the embryo exposure to UV. The ratio of C1q-like to β-actin in untreated embryos was set to 1 in every stage, and all UV treated embryos were normalized relative to this value. The data represent mean ± SD of three separate experiments. *p < 0.05 and **p < 0.01. (B) Normal phenotype of control wild-type embryo (a) and the UV exposed embryo phenotypes revealed by TUNEL assays in wild-type (b), p53 MO (c) and C1q-like mRNA injected (d) embryos. Each picture represents typical result from three experiments (more than 20 embryos in each experiment).
Reprinted from Developmental Biology, 319(2), Mei, J., Zhang, Q.Y., Li, Z., Lin, S., and Gui, J.F., C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis, 273-284, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.