ZFIN Image: Martin et al., 2008, Fig. 7

Image

Figure Caption

Fig. 7 Ntl Regulates wnt8 and wnt3a Expression without Intervening Protein Synthesis

(A-F) The expression of wnt8 and (G-J) wnt3a in control EtOH-treated or dex-treated embryos injected with ntl-GR mRNA.

(B) Continuous treatment with dex until shield stage increased wnt8 expression compared to (A) controls.

(C-F) Chx treatment at shield stage followed by dex treatment for 1 or 2 hr also increased wnt8 expression.

(G-J) Chx treatment at 75% epiboly followed by 2 hr of dex treatment increased wnt3a expression. Control embryos were treated with EtOH (A) or EtOH plus chx (C, E, G, and I).

(A)-(H) are ventral views, animal pole at top; (I) and (J) are vegetal views.

Acknowledgments

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Reprinted from Developmental Cell, 15(1), Martin, B.L., and Kimelman, D., Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation, 121-133, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell