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Fig. S6 Ectopic expression of dominant negative FGFR results in similar phenotypes as ERK1 and ERK2 morphants at 48 hpf. Injection of 250 pg synthetic mRNA encoding dominant negative FGFR1 (XFD), or dominant negative FGFR4 (bΔFR4), resulted in different phenotypes at 48 hpf, of which one class (indicated with an asterisk) was highly similar to the phenotypes observed in ERK1 and ERK2 morphants at 48 hpf. Over-expression of MKP3 did not lead to any obvious phenotypes at this concentration.
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Reprinted from Developmental Biology, 319(2), Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E., Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation, 370-383, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.