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Fig. 9 The domains of the Hh target genes ptc1 and ptc2 are expanded in blowout. Expression of ptc1 in the optic stalk of wild-type embryos at 24 hpf (A) and 30 hpf (C). (B, D) Expression in blw mutants is expanded and appears more intense at these time points both in the optic stalk, as well as in the brain and musculature (not shown). ptc2 expression is also expanded in blw mutants (F) relative to wild-type siblings (E).
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Reprinted from Developmental Biology, 319(1), Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M., Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye, 10-22, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.