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Fig. 4 Optic stalk morphology is abnormal in blowout. Single 1.25 μm oblique histological sections taken from 31 hpf wild-type (A) and blw (B) embryos taken at the same plane of sectioning. The optic stalk in blw is larger and kinked at the distal end (arrow in panel B). Optic stalk tissue is present at the choroid fissure and appears to prevent the lateral edges of the fissure from meeting and fusing (arrowhead).
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Reprinted from Developmental Biology, 319(1), Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M., Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye, 10-22, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.