ZFIN Image: Anderson et al., 2008, Fig. 2

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Figure Caption

Fig. 2 Aortic arches 5 and 6 exhibit delayed lumenization and fail to properly connect to the lateral dorsal aortae in kus^tr12 mutants. In wild type embryos, aortic arches 5 and 6 are lumenized by 50 hpf (A) and exhibit strong blood flow by 52 hpf (C). In kus^tr12 (B, D), lumenization is delayed by 2–3 h and blood cells accumulate in distal portions of aortic arch 5 (arrow). This accumulation of blood cells is accompanied by failure of the AA5X to make a patent connection to the LDA [compare E (WT) to F (kus^tr12)]. A–F, 2D confocal projections of TG(flk1:GFP^la116; gata1:dsRed) embryos at 50 hpf (A, B) or 52 hpf (C–F), labeling endothelial and blood cells green and red, respectively. A–D, lateral views, anterior to the left. E, F, dorsal views, anterior to the left.

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Acknowledgments

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Reprinted from Developmental Biology, 318(2), Anderson, M.J., Pham, V.N., Vogel, A.M., Weinstein, B.M., and Roman, B.L., Loss of unc45a precipitates arteriovenous shunting in the aortic arches, 258-267, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.