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Fig. 1 psoriasis mutants have epidermal defects. A: Wild-type and psoriasis (bottom) embryos at 60 hours postfertilization (hpf). psoriasis embryos develop pericardial edema (arrowhead) and epidermal aggregates (arrows). B-E: Wild-type (B,D) and psoriasis (C, E) embryos at 60 hpf showing regions of ectopic skin aggregates in psoriasis. F-H: Wild-type (F) and psoriasis (G,H) embryos stained for the epidermal-specific nuclear marker, p63. Note the presence of p63 within epidermal clumps (brackets). Anterior is to the left in A-E and to the upper left in F-H. Scale bars = 250 μm in A, 50 μm in B-E, 12.5 μm in F-H.