ZFIN Image: Ignatius et al., 2008, Fig. 7

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Figure Caption

Fig. 7 Genetically reducing foxd3 rescues melanophore development in hdac1^col-/-;foxd3^zdf10+/- mutants. (A–E) Live images with lateral views of 3.5 dpf embryos. Embryos obtained from a heterozygous incross of hdac1^col+/-;foxd3^zdf10+/- carriers gave rise to 4 distinct phenotypes. (A) Wild-type that have melanophores present in 4 distinct stripes: dorsal, lateral, ventral and yolk. (B) foxd3^zdf10 mutants in which the melanophore migration patterns have largely recovered to resemble the wild-type. (C) hdac1^col-/-;foxd3^zdf10+/+ and hdac1^col-/-;foxd3^zdf10+/- mutants whose melanophore phenotype resembles single hdac1^col-/- homozygous mutant phenotype. (D) hdac1^col-/-;foxd3^zdf10-/- double mutants in which there is a reduction in melanophore numbers as well as reduced migration into the lateral, ventral and yolk stripe locations. (E) 10% of phenotypically hdac1^col mutants that are hdac1^col-/-;foxd3^zdf10+/- display a rescue of melanophore number as well as migration into the lateral, ventral and yolk stripes.

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Acknowledgments

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Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.