Fig. 1

Fig. 1 Melanophore development is defective in hdac1^col mutants. Lateral views of live embryos at 27 hpf (A, B) and 3 dpf (C, D). (A, B) At 27 hpf in wild-type embryos melanophores are present posterior to the eye and otic vesicle and are migrating over the flank of the embryo. In hdac1^col mutants, there are fewer melanophores and most of the melanophores are located posterior to the otic vesicle (arrowhead). There are no migrating melanophores in hdac1^col mutants. (C, D) By 3 dpf, melanophores are present in four stripes in wild-type: dorsal (d), lateral (l), ventral (v) and yolk (y). In hdac1^col mutants melanophore numbers do not recover. Melanophores present in hdac1^col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otic vesicle (arrows, arrowhead). Melanophores that do migrate ventrally in hdac1col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otp>col mutants are present in the anterior ventral stripe over the yolk extension. Xanthophores, which give a yellowish hue to embryos, are present in the head and over the flank of wild-type embryos and hdac1^col mutants.