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Fig. 2 Expression patterns of Fgf19 in zebrafish embryonic eye. The expression patterns were determined by whole mount in situ hybridization. (a) Fgf19 was expressed in the future nasal retina at 18 hpf as indicated by an arrow. (b) By 20 hpf, the expression was confined to the anterior half of the neural retina as indicated by an arrow. Fgf19 expression in the lens was first detected at 20 hpf as indicated by an arrowhead. (c) Fgf19 expression intensified in the nasal retina and the lens at 27 hpf as indicated by an arrow and an arrowhead, respectively. (d) Fgf19 expression was detected in the inner region of the retina at 48 hpf as indicated by an arrow. (e, f) Fgf19 expression in the inner region of the retina was detected until 72 hpf as indicated by an arrow. (a–e) Lateral views with anterior to the left and dorsal to the top. (f) A transverse eye section at 72 hpf.
Reprinted from Developmental Biology, 313(2), Nakayama, Y., Miyake, A., Nakagawa, Y., Mido, T., Yoshikawa, M., Konishi, M., and Itoh, N., Fgf19 is required for zebrafish lens and retina development, 752-766, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.