ZFIN Image: Smith et al., 2008, Fig. S2

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Figure Caption

Fig. S2 Defects in Cardiac Jogging Are Synergistically Enhanced upon Combined Moderate Knockdown of Has2 and Bmp4 (A,B) Injection of moderate amount of has2 MO has no visible effect on the embryo nor on cardiac jogging (0.4 ng has2 MO, 68/73 embryos). (C,D) Injection of a moderate amount of bmp4 MO results in a mild reduction of the ventral tail fin (*) but no effect on cardiac jogging (0.4 ng bmp4 MO, 71/73 embryos). (E,F) Co-injection of moderate amounts of has2 and bmp4 MO leads to synergistic enhancement of the cardiac jogging defect (17/63 embryos) without affecting dorsalventral patterning indicated by the only very mild reduction of the ventral tail fin (*). Arrow indicatFi> and bmp4 MO les pericardial edema. (A,C,E) Lateral views of live embryos, (B,D,F) dorsal views with anterior to the top of in situ hybridizations with an antisense cmlc2 riboprobe.

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Acknowledgments

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Reprinted from Developmental Cell, 14(2), Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., and Bakkers, J., Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells, 287-297, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell