|
Fig. 3 Phenotype of nof homozygotes; wt: wild-type sibling. In A-I,K,M, anterior is to the left; in J,L,N proximal is to the left. (A,C) Lateral, (B,D) dorsal, (E-N) ventral views. (A-D) Larvae on day 5; ga, gill arches; pc, pericardial cavity; swb, swim bladder. (E,G) Branchial arch primordium of 36 hours embryos. (F) Presence and (H) absence of pectoral fin bud and AER marker dlx2 at 28 hours. (I,K) Cartilage pattern in heads and (J,L) fins of day 5 larvae. M, mandibular and H, hyoid arches; 3-7, gill arches; c, cleithrum; d, distal fin skeleton; g, proximal pectoral girdle. (M) Rescue of arch cartilages and (N) pectoral fins by treatment of nof homozygotes with 10–9 M retinoic acid at 30% epiboly until 16 hours.